See also entries under syndrome. Addison's disease bronzelike pigmentation of the skin, severe prostration, progressive anemia, low blood pressure, diarrhea, and digestive disturbance, due to adrenal hypofunction. Alpers' disease a rare disease of young children, characterized by neuronal deterioration of the cerebral cortex and elsewhere, progressive mental deterioration, motor disturbances, seizures, and early death. Alzheimer's disease progressive degenerative disease of the brain, of unknown cause; characterized by diffuse atrophy throughout the cerebral cortex with distinctive histopathological changes. ASCVD) atherosclerotic involvement of arteries to the heart and to other organs, resulting in debility or death; sometimes used specifically for ischemic heart disease. Ayerza's disease polycythemia vera with chronic cyanosis, dyspnea, bronchitis, bronchiectasis, hepatosplenomegaly, bone marrow hyperplasia, and pulmonary artery sclerosis. Barlow disease scurvy in infants. Binswanger's disease a degenerative dementia of presenile onset caused by demyelination of the subcortical white matter of the brain. United States and Australia, due to Clostridium novyi, marked by necrotic areas in the liver. Bowen's disease a squamous cell carcinoma in situ, often due to prolonged exposure to arsenic; usually occurring on sun- exposed areas of skin. The corresponding lesion on the glans penis is termed erythroplasia of Queyrat. Brill- Zinsser disease mild recrudescence of epidemic typhus years after the initial infection, because Rickettsia prowazekii has persisted in body tissue in an inactive state, with humans as the reservoir. CPDD) an acute or chronic inflammatory arthropathy caused by deposition of calcium pyrophosphate dihydrate (CPPD) crystals in the joints, chondrocalcinosis, and crystals in the synovial fluid. Acute attacks are sometimes called pseudogout. Calv. The most commonly seen are spongiform degeneration of neurons, neuronal loss, gliosis, and amyloid plaque formation, accompanied by rapidly progressive dementia, myoclonus, motor disturbances, and encephalographic changes, with death occurring usually within a year of onset. Crigler- Najjar disease see under syndrome. Crohn's disease regional enteritis; a chronic granulomatous inflammatory disease usually in the terminal ileum with scarring and thickening of the wall, often leading to intestinal obstruction and formation of fistulas and abscesses. Cushing's disease Cushing's syndrome in which the hyperadrenocorticism is secondary to excessive pituitary secretion of adrenocorticotropic hormone. Celiac Disease in Adults. Celiac disease, whether called gluten-sensitive enteropathy or non-tropical sprue, is one of a number of diseases that disrupt the. Celiac disease and gluten-free diet information at Celiac.com. Celiac disease, also known as gluten intolerance, is a genetic disorder that affects at least 1 in 133. People with celiac disease should stop eating gluten-free foods and focus on eating healthy. This is the way to the healing that we need and deserve. The diagnosis of celiac disease involves serologic testing (generally for IgA anti–tissue transglutaminase antibodies first) followed by upper endoscopy with biopsy. In the congenital form, there is hepatosplenomegaly with cirrhosis, and microcephaly with mental or motor retardation. Acquired disease may cause a clinical state similar to infectious mononucleosis. When acquired by blood transfusion, postperfusion syndrome results. Dukes' disease a febrile disease of childhood marked by an exanthematous eruption, probably due to a virus of the Coxsackie- ECHO group. Ebola virus disease fatal acute hemorrhagic fever resembling Marburg virus disease but caused by Ebola virus, seen in the Sudan and Zaire. Ebstein's disease see under anomaly. Fabry's disease an X- linked lysosomal storage disease of glycosphingolipid catabolism resulting from deficiency of . The adult form is associated with moderate anemia and thrombocytopenia, and yellowish pigmentation of the skin; in the infantile form there is, in addition, marked central nervous system impairment; in the juvenile form there are rapidly progressive systemic manifestations but moderate central nervous system involvement. Gilbert disease a familial, benign elevation of bilirubin levels without evidence of liver damage or hematologic abnormalities. Gilles de la Tourette's disease see under syndrome. Iglucose- 6- phosphatase deficiency: a severe hepatorenal form due to deficiency of the hepatic enzyme glucose- 6- phosphatase, resulting in liver and kidney involvement, with hepatomegaly, hypoglycemia, hyperuricemia, and gouttype IB a form resembling type I but additionally predisposing to infection due to neutropenia and to chronic inflammatory bowel disease; due to a defect in the transport system for glucose 6- phosphate. Hartnup disease a hereditary disorder of intestinal and renal transport of neutral . Reed- Sternberg cells are characteristically present. Four types have been distinguished on the basis of histopathologic criteria. Ancylostoma duodenale or Necator americanus, whose larvae enter the body through the skin or in contaminated food or water and migrate to the small intestine where, as adults, they attach to the mucosa and ingest blood; symptoms may include abdominal pain, diarrhea, colic or nausea, and anemia. Echinococcus, marked by development of expanding cysts. Gluten-sensitive enteropathy or, as it is more commonly called, celiac disease, is an autoimmune inflammatory disease of the small intestine that is precipitated by. It may affect the whole body or any of its parts, and its. X- linked hypophosphatemia, similarly due to a defect in renal tubular function but usually showing osteomalacia without radiographic evidence of rickets. III hypersensitivity reactions. Crohn's disease and ulcerative colitis. IHD) any of a group of acute or chronic cardiac disabilities resulting from insufficient supply of oxygenated blood to the heart. Jansk. It is often associated with vasculitis of the large coronary vessels. Kienb. Pathologically, there is rapidly progressive cerebral demyelination and large globoid bodies (swollen with accumulated cerebroside) in the white substance. Kufs' disease the adult form of neuronal ceroid lipofuscinosis, with onset prior to age 4. K. Raynaud's disease a primary or idiopathic vascular disorder, most often affecting women, marked by bilateral attacks of Raynaud's phenomenon. Refsum's disease an inherited disorder of lipid metabolism, characterized by accumulation of phytanic acid, chronic polyneuritis, retinitis pigmentosa, cerebellar ataxia, and persistent elevation of protein in cerebrospinal fluid. Roger's disease a ventricular septal defect; the term is usually restricted to small, asymptomatic defects. Salla disease an inherited disorder of sialic acid metabolism characterized by accumulation of sialic acid in lysosomes and excretion in the urine, mental retardation, delayed motor development, and ataxia. Sandhoff's disease a type of GM2 gangliosidosis resembling Tay- Sachs disease, seen in non- Jews, marked by a progressively more rapid course, and due to a defect in hexosaminidase, both isozymes A and B. Schamberg's disease a slowly progressive purpuric and pigmentary disease of the skin affecting chiefly the shins, ankles, and dorsa of the feet. Schilder's disease subacute or chronic leukoencephalopathy in children and adolescents, similar to adrenoleukodystrophy; massive destruction of the white substance of the cerebral hemispheres leads to blindness, deafness, bilateral spasticity, and mental deterioration. Sch. See also obstructive small airways d. ADP) in response to aggregating agents; characterized by mild bleeding episodes, prolonged bleeding time, and reduced aggregation response to collagen or thrombin. Str. Disease may be caused by developmental disturbances, genetic factors, metabolic factors, living agents, or physical, chemical, or radiant energy, or the cause may be unknown. Adams- Stokes (Adams- Stokes syndrome),n. Cheyne- Stokes respirations. See also syndrome, general adaptation. Addison's,n. pr a chronic adrenocortical insufficiency caused by bilateral tuberculosis, aplasia, atrophy, or degeneration of the adrenal glands. Symptoms include severe weakness, weight loss, low blood pressure, digestive disturbances, hypoglycemia, lowered resistance to infection, and abnormal pigmentation (bronze color of the skin, with associated melanotic pigmentation of the oral mucosa, especially of the gingival tissues). Addison's disease, Cushing's syndrome, adrenogenital syndrome, and primary aldosteronism. See disease, autoimmune. Includes various hemolytic anemias, idiopathic thrombocytopenias, rheumatoid arthritis, systemic lupus erythematosus, glomerulonephritis, scleroderma, Hashimoto's thyroiditis, and Sj. Such a disease often results in lesions of the oral structures, particularly the mucosal surfaces. Brill- Symmers,n. See lymphoblastoma, giant follicular. B. Local lesions occur at the site of injury with a regional adenitis that is out of proportion to the primary lesion occurring within 1 to 3 weeks. Systemic symptoms of infection may occur. Diagnosis is confirmed by serologic tests. See disease, autoimmune. COPD),n a disease marked by decreased expiratory flow rates resulting in increased total lung capacity. Porcelain gallbladder is a calcification of the gallbladder believed to be brought on by excessive gallstones, although the exact cause is not clear. Chronic diarrhea, defined as a decrease in stool consistency for more than four weeks, is a common but challenging clinical scenario. It can be divided into three. The Linus Pauling Institute's Micronutrient Information Center is a source for scientifically accurate information regarding the roles of vitamins, minerals. Patients with this condition are prone to acute respiratory failure from infections or general anesthesia. These diseases have similar biochemical structural alterations and include rheumatic fever, scleroderma, rheumatoid arthritis, systemic lupus erythematosus, periarteritis, and serum sickness. A disease with the capacity for maintenance by natural modes of spread (e. Cushing's,n. pr hypercortisolism that results from an adrenal or pituitary neoplasm. The term Cushing's syndrome refers to hypercortisolism that is not related to an endogenous process. See disease, salivary gland. Darier's (keratosis follicularis),n. The oral lesions are whitish papules of the gingiva, tongue, or palate. It is characterized histologically by the presence of corps ronds. Used mainly in reference to avitaminosis. Often used to mean members of the same generation and occasionally used synonymously with hereditary disease. The secretion of the affected mucous glands is abnormally viscous. B1. 9; spread via the upper respiratory tract, this virus impacts on children more strongly than adults. Also called erythema infectiosum. Gaucher's(g. This glycoprotein accumulates in the reticuloendothelial system and leads to splenomegaly, hepatomegaly, lymph node enlargement, and bone defects. GVHD),n a potentially deadly condition resulting from allogenically transplanted hematopoietic cells that reject host cells in the transplant recipient.
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